C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2460665
The present invention relates to molecules binding to specific targets comprising Glu-Pro (EP) repeated motifs, namely to molecules binding to a target comprising an EP motif having the following sequence [X- (EP)n-Y-(EP)m- Z]p wherein X, Y and Z, identical or different comprise a sequence of 0 to 10 aminoacids, identical or different, n, m are integers comprised between 0 to 20, preferably between 3 to 10 at least one from n or m being different from 0 and p is an integer comprised between 1 and 10. The invention relates also to pharmaceutical compositions containing them, to antibodies directed against them and to methods useful for screening drugs by using them.
L'invention concerne des molécules se liant avec des cibles spécifiques qui comprennent des motifs Glu-Pro (EP) répétés. Il s'agit de molécules se liant avec une cible dans laquelle on trouve un motif EP de séquence [X- (EP)¿n?-Y-(EP)¿m?-Z]¿p?. Dans cette séquence, X, Y et Z, identiques ou différents, comprennent une séquence de 0 à 10 aides aminés, identiques ou différents; n et m son des entiers valant entre 0 et 20, de préférence entre 3 et 10, sachant qu'au moins l'un des entiers n ou m est différent de 0; et p est un entier compris entre 1 et 10. L'invention concerne également des compositions pharmaceutiques renfermant ces molécules, des anticorps vis-à-vis des molécules en question, et des procédés utiles pour le criblage de médicaments via lesdites molécules.
Gowling Lafleur Henderson Llp
Institut Gustave Roussy - Igr
Universite Paris-Sud
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