C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/20 (2006.01) A61K 38/46 (2006.01) A61K 39/35 (2006.01)
Patent
CA 2360082
The invention concerns peptides and proteins for desensitizing specifically the vast majority of subjects allergic to bee venom and compositions containing said peptides or proteins. The peptides are selected in the group consisting of: the fragment (1) corresponding to positions P85-97 of the major bee venom allergen, the fragment (2) corresponding to positions P81-93 of the major bee venom allergen, the fragment (3) corresponding to positions P94-106 of the major bee venom allergen, the fragment (4) corresponding to positions P76-88 of the major bee venom allergen, the fragment (5) corresponding to positions P77-94 of the major bee venom allergen, and the fragment (6) corresponding to positions P122-134 of the major bee venom allergen, fragments (1) and (2) forming group (I); fragment (3) forming group (II); fragments (4) and (4) forming group (III) and fragment (6) forming group IV and the mutated fragments of said fragments (1) to (6) which have a binding activity with MHC class (II) molecules identical or higher than those of said fragments (1) to (6). The invention also concerns compositions containing said peptides or proteins.
Peptides et protéines aptes à désensibiliser, de manière spécifique, la grande majorité des sujets allergiques au venin d'abeille, ainsi que compositions contenant lesdits peptides ou protéines. Les peptides sont sélectionnés dans le groupe constitué par: le fragment (1) correspondant aux positions P85-97 de l'allergène majeur du venin d'abeille, le fragment (2) correspondant aux positions P81-93 de l'allergène majeur du venin d'abeille, le fragment (3) correspondant aux positions P94-106 de l'allergène majeur du venin d'abeille, le fragment (4) correspondant aux positions P76-88 de l'allergène majeur du venin d'abeille, le fragment (5) correspondant aux positions P77-94 de l'allergène majeur du venin d'abeille, et le fragment (6) correspondant aux positions P122-134 de l'allergène majeur du venin d'abeille, les fragments (1) et (2) formant le groupe (I); le fragment (3) formant le groupe (II); les fragments (4) et (5) formant le groupe (III) et le fragment (6) formant le groupe (IV) et les fragments mutés desdits fragments (1) à (6) qui présentent une activité de liaison aux molécules du CMH de classe (II) identiques ou supérieures à celles desdits fragments (1) à (6). Compositions contenant lesdits peptides ou protéines.
Maillere Bernard
Menez Andre
Pouvelle Sandra
Texier Catherine
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