Peptides as ns3-serine protease inhibitors of hepatitis c virus

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/02 (2006.01) A61K 38/55 (2006.01) A61P 31/14 (2006.01) C07K 14/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2418199

The present invention discloses novel peptide compounds containing eleven amino acid residues which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such peptides as well as methods of using them to treat disorders associated with the HCV protease.

La présente invention concerne des nouveaux composés peptidiques contenant onze restes d'acides aminés présentant une activité inhibitrice de protéase du virus de l'hépatite C. L'invention concerne également des procédés permettant de préparer de tels composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant de tels peptides, ainsi que des procédés permettant de les utiliser pour traiter des troubles associés à la protéase du virus de l'hépatite C.

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