Peptides as solubilizing excipients for transforming growth...

Details Peptides as solubilizing excipients for transforming growth... Peptides as solubilizing excipients for transforming growth...

A - Human Necessities

61

K

A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/495 (2006.01) C07K 14/51 (2006.01)

Patent

CA 2495222

The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP- 2.

L'invention porte sur des compositions contenant des excipients ou des agents de solubilisation pour protéines. Cette invention concerne la découverte selon laquelle un peptide issu de l'extension N-terminal de l'isoforme T266 de rhBMP2 possède des propriétés capables d'améliorer la solubilité des protéines. Cette invention porte également sur des procédés de resolubilisation d'une protéine qui a été précipitée, par la mise en contact de la protéine avec un peptide constitué de l'extension d'acide aminé 17 de l'isoforme T266 de rhBMP-2. Cette invention concerne aussi des procédés permettant d'augmenter la solubilité d'une protéine par mise en contact de la protéine avec un peptide constitué de l'extension d'acide aminé 17 de l'isoforme T266 de rhBMP-2.

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