Peptides binding the phosphatase 2a protein and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/00 (2006.01)

Patent

CA 2502411

The invention concerns novel synthetic or natural E4orf4 or Bcl-2 peptides useful in particular in antitumoral, antiviral and antiparasitic treatments, said peptides having dimensions less than 33 amino acids and characterized in that they bind in vitro a phosphatase 2A protein holoenzyme or one of its subunits. The invention also concerns polynucleotides encoding the novel peptides, vectors expressing same, as well as antibodies identifying same and probes identifying transcripts thereof.

L'invention a trait à de nouveaux peptides E4orf4 ou Bcl-2 synthétiques ou naturels utiles en particulier dans les traitement anti-tumoraux, antiviraux et antiparasitaires, lesdits peptides étant de tailles inférieures à 33 acides aminés et caractérisés en ce qu'ils lient in vitro une holoenzyme protéine phosphatase 2A ou l'une de ses sous-unités. L'invention a aussi trait aux polynucléotides encodant les nouveaux peptides, aux vecteurs les exprimant, ainsi qu'aux anticorps les reconnaissant et aux sondes reconnaissant leurs transcrits.

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