Peptides blocking vascular endothelial growth factor...

Details Peptides blocking vascular endothelial growth factor... Peptides blocking vascular endothelial growth factor...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61P 3/10 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01) C07K 5/09 (2006.01) C07K 14/515 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C12N 1/20 (2006.01) C12N 5/06 (2006.01) C12N 15/10 (2006.01) C12N 15/66 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/80 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2404528

The present invention provides peptides which can interact with VEGF and inhibit VEGF interaction with KDR or anti-VEGF antibody thereby inhibiting VEGF mediated angiogenesis or angiogeneis related diseases, polynucleotide encoding the peptides, vectors containing the polynucleotides, pharmaceutical compositions containing the peptides, and methods of inhibiting angiogenesis with the peptides.

L'invention concerne des peptides qui peuvent interagir avec le VEGF et inhiber l'interaction du VEGF avec le KDR ou l'anticorps anti-VEGF, inhibant ainsi l'angiogenèse activée par le VEGF ou des maladies liées à l'angiogenèse. L'invention concerne également des polynucléotides codant pour ces peptides, des vecteurs contenant ces polynucléotides, des compositions pharmaceutiques contenant ces peptides ainsi que des procédés d'inhibition de l'angiogenèse à l'aide de ces peptides.

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