Peptides containing n-substituted d-amino acids for...

Details Peptides containing n-substituted d-amino acids for... Peptides containing n-substituted d-amino acids for...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2379241

Chemical compounds and compositions are disclosed which comprise peptides composed of D-enantiomers of amino acids and capable of binding to .beta.- strand structures to form .beta.-sheets, said peptides being selectively N.alpha.-substituted to prevent further .beta.-strand association. The peptides are useful for preventing .beta.-strand association.

L'invention concerne des composés chimiques et des compositions comprenant des peptides constitués d'énantiomères en D d'acides aminés et pouvant se lier à des structures de brins-.beta. de manière à former des feuillets-.beta., ces peptides étant N.alpha.-substitués de manière sélective afin d'empêcher d'autres associations de brins-.beta.. Les peptides sont utiles pour empêcher les associations de brins-.beta..

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