C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/065 (2006.01) A61K 38/05 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2489463
The present invention relates to compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle les groupes de variables sont définis dans la description, à des sels pharmaceutiquement acceptables, à des solvates, à des solvates de ces sels et à des promédicaments de ces composés ainsi qu'à leur utilisation en tant qu'inhibiteurs du transport iléal des acides biliaires (IBAT) pour le traitement de l'hyperlipidémie. L'invention se rapporte également à des procédés de fabrication de ces composés et des compositions pharmaceutiques contenant ces derniers.
Alenfalk Suzanne
Dahlstrom Mikael Ulf Johan
Lemurell Malin
Skjaret Tore
Starke Ingemar
Astrazeneca Ab
Fetherstonhaugh & Co.
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