C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61P 19/02 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2391356
The present invention relates to peptides that mimic the immunogenic determinants of self-proteins recognised by autoimmune antibodies in a biological sample from patients suffering from rheumatoid arthritis (RA). More particularly, the present invention relates to citrulline-containing peptides, which react with the majority of the latter antibodies. Furthermore, the present invention relates to diagnostic tools for a more convenient and sensitive diagnosis of RA and to therapeutical methods to treat RA.
L'invention concerne des peptides qui miment les déterminants immunogéniques de d'auto-protéines reconnus par des anticorps auto-immunes d'un échantillon biologique prélevé sur des patients souffrant de polyarthrite rhumatoïde. L'invention concerne plus particulièrement des peptides contenant une citrulline, qui réagissent avec la majorité des derniers anticorps. L'invention concerne enfin des outils de diagnostic permettant d'établir un diagnostic plus facile et plus sensible de la polyarthrite rhumatoïde, et des méthodes thérapeutiques permettant de traiter ladite polyarthrite rhumatoïde.
Meheus Lydie
Moereels Henri
Union Ann
Innogenetics N.v.
Smart & Biggar
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