Peptides for inducing cytotoxic t lymphocyte responses to...

Details Peptides for inducing cytotoxic t lymphocyte responses to... Peptides for inducing cytotoxic t lymphocyte responses to...

C - Chemistry, Metallurgy

12

N

C12N 15/36 (2006.01) A61K 35/14 (2006.01) A61K 39/29 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/02 (2006.01) C12N 9/12 (2006.01) A61K 39/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2168583

Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV polymerase, and are particularly useful in treating or preventing HBV infection, including methods for stimulating the immune response of chronically infected individuals to respond to HBV antigens.

Peptides utilisés pour définir des déterminants antigéniques qui stimulent l'activité du lymphocyte T cytotoxique à HLA restreint contre les antigènes du virus de l'hépatite B (HBV). Les peptides sont dérivés de régions de la polymérase HBV et sont particulièrement utiles dans le traitement ou la prophylaxie de l'infection HBV ainsi que dans des procédés de stimulation de la réponse immunitaire d'individus sujets à des infections chroniques pour répondre aux antigènes HBV.

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