C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/18 (2006.01) A61K 39/29 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 7/04 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2184890
The present invention is directed to a molecule comprising a polypeptide having substantial homology with a CTL epitope selected from the group consisting of ADLMGYIPLV (Core131-140; SEQ ID NO:1), LLALLSCLTV (Core178-187; SEQ ID NO:2), QLRRHIDLLV (SEQ ID NO:55), LLCPAGHAV (NS31169-1177; SEQ ID NO:26), KLVALGINAV (NS31406-1415; SEQ ID NO:28), SLMAFTAAV (NS41789-1797; SEQ ID NO:34), LLFNILGGWV (NS41807-1816; SEQ ID NO:35), and ILDSFDPLV (NS52252- 2260); SEQ ID NO:42). Such molecules are used for the treatment and prevention of acute or chronic HCV hepatitis; suitable pharmaceutical compositions and methods using such compositions are disclosed.
L'invention concerne une molécule comprenant un polypeptide présentant une homologie sensible vis-à-vis d'un épitope de lymphocyte T cytotoxique (CTL), sélectionné dans le groupe constitué de ADLMGYIPLV (Noyau¿131-140?; SEQ ID NO:1), LLALLSCLTV (Noyau¿178-187?; SEQ ID NO:2), QLRRHIDLLV (SEQ ID NO:55), LLCPAGHAV (NS3¿1169-1177?; SEQ ID NO:26), KLVALGINAV (NS3¿1406-1415?; SEQ ID NO:28), SLMAFTAAV (NS4¿1789-1797?; SEQ ID NO:34), LLFNILGGWV (NS4¿1807-1816?; SEQ ID NO:35), et ILDSFDPLV (NS5¿2252-2260?); SEQ ID NO:42). On utilises ces molécules dans le traitement et la prévention de lhépatite VHC aigüe ou chronique; l'invention concerne également des compositions pharmaceutiques appropriées ainsi que leurs modes d'utilisation.
Cerny Andreas
Chisari Francis V.
Borden Ladner Gervais Llp
The Scripps Research Institute
LandOfFree
Peptides for inducing cytotoxic t lymphocyte responses to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptides for inducing cytotoxic t lymphocyte responses to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides for inducing cytotoxic t lymphocyte responses to... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1794873