Peptides for neutralizing the toxicity of lipid a

Details Peptides for neutralizing the toxicity of lipid a Peptides for neutralizing the toxicity of lipid a

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 31/00 (2006.01) A61P 39/00 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2167087

The present invention is concerned with a peptide composition which includes a peptide having units of the formula: (a) (A)n wherein A is Lysine or Arginine and n is an integer with a minimum value of 7. (b) (AB)m wherein A is Lysine or Arginine and B is a hydrophobic amino acid selected from the group consisting of Valine, Leucine, Isoleucine, Tyrosine, Phenylalanine and Tryptophan; m is an integer with a minimum value of 3; and (c) (ABC)p wherein A is a cationic amino acid which is Lysine or Arginine; B and C are hydrophobic amino acids which may be the same or different and are selected from the group consisting of Valine, Leucine, Isoleucine, Tyrosine, Phenylalanine and Tryptophan; p is an integer with a minimum value of 2. The compositions of the invention bind Lipid-A of endotoxins.

Composition peptidique comprenant un peptide présentant les unités de la formule (a) (A)n dans laquelle A représente Lysine ou Arginine et n est un nombre entier ayant une valeur minimale de 7; (b) (AB)m, dans laquelle A représente Lysine ou Arginine et B représente un acide aminé hydrophobe sélectionné dans le groupe constitué de Valine, Leucine, Isoleucine, Tyrosine, Phénylalanine et Tryptophane, et m est un nombre entier ayant une valeur minimale de 3; et (c) (ABC)p, dans laquelle A représente un acide aminé cationique qui est Lysine ou Arginine; B et C, identiques ou différents, sont des acides aminés hydrophobes sélectionnés dans le groupe constitué de Valine, Leucine, Isoleucine, Tyrosine, Phénylalanine et Tryptophane; et p est un nombre entier ayant une valeur minimale de 2. Ces compositions se lient au Lipide A d'endotoxines.

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