A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2488968
Compositions of the polypeptide EEIIMI, Ac-RMAPEEIMDRPFLYVVR-amide, anti-LRP antibodies, LRP antagonists, and/or one or more fibrinolytic agents are formulated for enhancing the fibrinolytic activity, reducing the side effects due to vasoactivity caused by the fibrinolytic agents, and/or prologing the half lives of the fibrinolytic agents. The invention further relates to combination compositions and/or therapy regimens, comprising the polypeptide EEIIMI and/or Ac-RMAPEEIIMDRPFLYVVR-amide and one or more currently used plasminogen activators.
L'invention porte sur des compositions mixtes comprenant le polypeptide EEIIMI, l'amide Ac-RMAPEEIMDRPFLYVVR, des anticorps anti-LRP, des antagonistes de la LRP, et/ou des agents fibrinolytiques, ayant pour effet d'accroître l'activité fibrinolytiques, de réduire les effets secondaires dus à la vasoactivité causée par les agents fibrinolytiques et/ou de prolonger la demi-vie des agents fibrinolytiques. L'invention porte également sur des compositions mixtes et/ou sur des régimes thérapeutiques utilisant le polypeptide EEIIMI et/ou l'amide Ac-RMAPEEIIMDRPFLYVVR et un ou plusieurs activateurs du plasminogène usuels.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Thrombotech Ltd.
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