Peptides for suppression of myeloid progenitor cell...

Details Peptides for suppression of myeloid progenitor cell... Peptides for suppression of myeloid progenitor cell...

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 4/12 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2162610

Peptides containing the sequence Ala-Lys-Pro-Arg have suppressive effects on the proliferation of a broad range of myelopoietic progenitor cells. In a preferred embodiment, the peptide has the sequence Glu-Thr-Val-Ile-Met-Lys-Ala-Lys-Pro-Arg-Ala-Asn-Phe-Pro. The peptides of the present invention are useful in the treatment of myelopoietic hyperproliferative disorders, and in protecting myeloid cells from damage induced by chemotherapy and radiation. Peptides containing the sequence Ala-Lys-Pro-Arg are also useful in the treatment of endotoxin-induced septic shock.

Des peptides contenant la séquence Ala-Lys-Pro-Arg présentent des effets suppresseurs sur la prolifération d'un large éventail de cellules souches myélopoïétiques. Dans un mode de réalisation préféré, le peptide présente la séquence Glu-Thr-Val-Ile-Met-Lys-Ala-Lys-Pro-Arg-Ala-Asn-Phe-Pro. Les peptides de l'invention sont utiles dans le traitement de troubles hyperprolifératifs myélopoïétiques, et dans la production de cellules myéloïdes contre une détérioration induite par chimiothérapie et par rayonnement. Des peptides contenant la séquence Ala-Lys-Pro-Arg sont également utiles dans le traitement du choc septique induit par endotoxine.

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