Peptides for use as translocation factors

Details Peptides for use as translocation factors Peptides for use as translocation factors

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 8/64 (2006.01) A61K 38/17 (2006.01) A61K 38/43 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61Q 17/04 (2006.01) A61Q 19/00 (2006.01) C07K 2/00 (2006.01) C07K 14/435 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2451236

Proteins that contain the amino acid sequence motif X1X1X2X3X1, where X1 = R or K and X2 and X3 = any amino acid have been found to translocate and can therefore be used in the manufacture of compositions for therapeutic applications. The proteins may also be used as translocation factors to deliver proteins or nucleic acids into a cell.

La présente invention concerne la découverte du fait que des protéines, qui contiennent le motif de séquence aminoacide X?1¿X?1¿X?2¿X?3¿X?1¿, où X?1¿ = R ou K et X?2¿ et X?3¿ = n'importe quel aminoacide, peuvent subir une translocation et peuvent par conséquent être utilisés dans la fabrication de compositions destinées à des applications thérapeutiques. Lesdites protéines peuvent également être utilisées en tant que facteurs de translocation pour libérer des protéines ou des acides nucléiques dans une cellule.

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