C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01)
Patent
CA 2650267
The present invention relates to peptides that are able to interact with ruptured atherosclerotic plaque-associated antibodies, which peptides comprise an immunoreactive part of one of the amino acid sequences according to SEQ ID NOS: 1-25. The invention further relates to a diagnostic reagent comprising the peptides, to the use of the method and to a method and test kit for the diagnosis of a sample from an individual for the presence therein of antibodies that are indicative of the presence of ruptured atherosclerotic plaques in the individual.
La présente invention concerne des peptides qui sont capables d'interagir avec des anticorps associés à un plaque d'athérosclérose rompue, les peptides comportant une partie immunoréactive de l'une des séquences d'acides aminés selon SEQ ID NO : 1 à 25. L'invention concerne en outre un réactif de diagnostic contenant les peptides, l'utilisation du procédé, ainsi qu'une méthode et une trousse d'essai destinées à diagnostiquer un échantillon issu d'un individu afin d'y déterminer la présence d'anticorps indicatifs de la présence de plaques d'athérosclérose chez l'individu.
Cleutjens Catharina Barbara Josephina Maria
Daemen Matthias Joseph Alphons Pieter
Gowling Lafleur Henderson Llp
Universiteit Maastricht / Carim
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