Peptides from gtpase-activating protein (gap) and diagnostic...

Details Peptides from gtpase-activating protein (gap) and diagnostic... Peptides from gtpase-activating protein (gap) and diagnostic...

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2065017

2065017 9102749 PCTABS00003 Peptides, that inhibit GAP stimulated ras p21 hydrolysis of GTP; peptides that mediate dissociation of GDP from ras p21-GTP complex; and antibodies to the peptides are described. These peptides are useful as cancer diagnostics and therapeutics, particularly to detect cancer cells with an over expression of normal or oncogenic ras p21 protein and to treat cancer caused by ras oncogene. Methods for assaying products of oncogenes using the described peptides and antibodies are also disclosed. Method for treating cancer caused by ras oncogenes is also disclosed. Prefered peptides are (Thr)-Met-Arg-Thr-Arg-Val-Val-Ser-Gly-Phe-Val-Phe-Lev-Arg-Lev-Ile-Cgs.

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