C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 51/08 (2006.01) A61M 1/34 (2006.01) A61M 1/36 (2006.01) A61P 7/02 (2006.01) A61P 29/00 (2006.01) C12N 15/12 (2006.01) G01N 33/58 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2491343
The invention concerns a peptide for specific recognition of lipid vectors. The inventive peptide comprises the following peptide sequence (I): J¿1?-J¿2?-J¿3?-J¿4?-J¿5?-J¿6?-Z¿7?-U¿8?-J¿9?-J¿10?-U¿11?-Arg-J¿13?-J¿14?-U¿15?-Lys-Gly-X¿18?-Gly-Thr-J¿21?-Glu-J¿23?-J¿24?-U¿25?-J¿26?-J¿27?-J¿28?-U¿29?-J¿30?-J¿31?-Arg-J¿33?-J¿34?-J¿35?-J¿36?-B¿37?-J¿38?-J¿39?-U¿40?-J¿41?-J¿42?-J¿43?-U¿44?-J¿45?-J¿46?-J¿47?-J¿48?-J¿49?-Arg-J¿51?-U¿52?-J¿53?-J¿54?-Asp-U¿56?-Lys-Ser-Z¿59?-Leu-J¿61?-J¿62?-J¿63?-J¿64?-Z¿65?-J¿66?-J¿67?-U¿68?-J¿69?-J¿70?-J¿71?-U¿72?-J¿73?-J¿74?-J¿75? (I), wherein the amino acids J are selected independently of one another among the essential amino acids, or derivatives thereof, such that at least 50 % among them are polar residues selected among Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr; the amino acids U are selected independently of one another among Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; amino acid X?18¿ is selected independently of the other amino acids of the sequence among Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr and Val; amino acid B?37¿ is selected independently of the other amino acids of the sequence among Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; amino acid Z?7¿ is selected independently of the other amino acids of the sequence among Asp and Gly; the amino acids Z?59¿ and Z?65¿ are selected independently of the other amino acids of the sequence among Glu, Asp, Lys or Arg; the exponents of the residues J, Z, U, X and B represent the position of those amino acids in said sequence.
La présente invention se rapporte à un peptide pour la reconnaissance spécifique de vecteurs lipidiques. Le peptide de l'invention comprend la séquence peptidique (I) suivante : J1-J2-J3-J4-J5-J6-Z7-U8-J9-J10-U11-Arg-J13- J14-U15-Lys-Gly-X18-Gly-Thr-J21-Glu-J23-J24-U25-J26-J27-J28-U29-J30-J31-Arg- J33-J34-J35-J36-B37-J38-J39-U40-J41-J42-J43-U44-J45-J46-J47-J48-J49-Arg-J51- U52-J53-J54-Asp-U56-Lys-Ser-Z59-Leu-J61-J62-J63-J64-Z65-J66-J67-U68-J69-J70- J71-U72-J73-J74-J75 (I)dans laquelle les acides aminés J sont choisis indépendamment les uns des autres parmi les acides aminés essentiels, ou des dérivés de ceux-ci, de telle manière que au moins 50% d'entre eux sont des résidus polaires choisis parmi Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr et Tyr ; les acides aminés U sont choisis indépendamment les uns des autres parmi Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr et Val ; l'acide aminé X18 est choisi indépendamment des autres acides aminés de la séquence parmi Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr et Val ; l'acide aminé B37 est choisi indépendamment des autres acides aminés de la séquence parmi Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr et Val ; l'acide aminé Z7 est choisi, indépendamment des autres acides aminés de la séquence parmi Asp et Gly ; les acides aminés Z59 et Z65 sont choisis parmi Glu, Asp, Lys ou Arg ; les exposants des résidus J, Z, U, X et B représentant la position de ces acides aminés dans ladite séquence.
Ochsenbein Francoise
Sanson Alain
LandOfFree
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