C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.64
C07K 7/64 (2006.01) C07K 7/06 (2006.01)
Patent
CA 1270100
ABSTRACT OF THE DISCLOSURE The invention relates to peptides of the formula II Image in which W represents Lys (R1), D-lys (R1), Arg (R2) or D-Arg (R2), X represents Lys (R1), D-Lys (R1), Arg (R2) or D-Arg (R2), Y represents Asp (R3), D-Asp (R3), Glu (R3) or D-Glu (R3), U represents Val or D-Val, D represents Tyr, D-Tyr, Trp, D-Trp, Phe or D-Phe, and in which R1 represents a urethane-protective group, R2 represents a protective group for the guanidino function and R3 represents an ester-protective group, and wherein (a) all five radicals a represent peptide bonds or (b) one of the radicals a represents a C-terminal OH together with an N-terminal H (a=OH H-) of two aminoacid radicals and the remaining four radicals a each denote peptide bonds, and processes for their preparation and their use. The peptides of the invention can be used for the synthesis of peptides of the Formula I. The latter can be used for the treatment of immunodeficiencies, viral, fungoidal and chronic bacterial infections and autoimmune diseases and for the therapy of diseases which are caused by cells with immunologically relevant changes in the cell membrane characteristics (for example tumor cells).
521657
Kessler Horst
Kutscher Bernhard
Mullner Hubert
Obermeier Rainer
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
Kessler Horst
Kutscher Bernhard
Mullner Hubert
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