Peptides having antagonistic activities to endothelin...

Details Peptides having antagonistic activities to endothelin... Peptides having antagonistic activities to endothelin...

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2061246

TITLE: PEPTIDES, PRODUCTION AND USE THEREOF ABSTRACT Disclosed are a peptide represented by formula (I) or a pharmaceutically acceptable salt thereof: Image (I) wherein M represents a mercaptoacyl group; P, Q, R, S, T, U, V, W, X, Y and Z each represent amino acid residues, wherein an amino acid side chain of Y is either a substituted saturated aliphatic hydrocarbon group having 1 to 15 carbon atoms or an unsubstituted saturated aliphatic hydrocarbon group having 4 to 15 carbon atoms other than (1S)-1-methylpropyl; (2) a method for producing the above- mentioned peptide or the salt thereof, which comprises subjecting a peptide represented by formula (II) or a salt thereof to an oxidation reaction: Image (II) wherein M, P, Q, R, S, T, U, V, W, X, Y and Z are as diefined above; and (3) use of the above-mentioned peptide or the pharmaceutically acceptable salt thereof as an anti- endothelin agent.

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