Peptides having farnesyl transferase inhibiting properties...

Details Peptides having farnesyl transferase inhibiting properties... Peptides having farnesyl transferase inhibiting properties...

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 38/08 (2006.01) C07K 7/06 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2184756

A Streptomyces No. CBS 154.94 strain, mutants or derivatives thereof, and a method for preparing peptides using said strain, are disclosed. Novel peptides of general formula (I), pharmaceutical compositions containing same, and the use thereof in cancer therapy, are also disclosed.

La présente invention concerne une souche de Streptomyces No. CBS 154.94 et ses mutants ou dérivés et un procédé de préparation de peptides mettant en oeuvre ladite souche. Elle se rapporte également à de nouveaux peptides définis par une formule générale (I), à des compositions pharmaceutiques les contenant et à leur utilisation dans les traitements anti-cancéreux.

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