C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/078 (2006.01) A61K 38/05 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 37/00 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2433582
The present invention relates to a compound of the formula (I)wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.
L'invention concerne un composant de formule (I) dans laquelle R1 représente un benzofuranyl substitué par un halogène ou un styryl substitué par un halogène, R2 est un hydroxy substitué, un mercapto substitué ou sulfony substitué et X est ou des sels pharmaceutiquement acceptables de ceux-ci. Le composant (I) décrit par la présente invention et les sels pharmaceutiquement acceptables de ceux-ci présentent une forte activité inhibitrice sur la production de monoxyde d'azote (NO) et servent à prévenir et/ou traiter des maladies induites par le NO affectant les êtres humains et les animaux.
Imamura Kenichiro
Ishibashi Naoki
Ohkawa Takehiko
Sato Kentaro
Shima Ichiro
Astellas Pharma Inc.
Fujisawa Pharmaceutical Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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