C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 11/00 (2006.01) C07C 225/06 (2006.01) C07C 321/04 (2006.01) C07H 21/00 (2006.01) C07K 1/04 (2006.01) C07K 1/10 (2006.01) C12P 19/04 (2006.01) C12P 19/34 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2442645
Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecules of the invention are made entirely by solid phase synthesis. In other instances, the spacer groups are hydrophilic and compositions containing them, and to solid phase synthesis of varied structure peptoids using chemoselective ligation moieties.
L'invention concerne des molécules présentant une activité biologique potentielle, en particulier des peptoïdes, conjugués à des supports en phase solide, des groupes espaceurs, et/ou des fragments de ligation, ainsi que leurs procédés de préparation. Dans certains cas, les molécules selon l'invention sont préparées entièrement par synthèse en phase solide. Dans d'autres cas, les groupes espaceurs sont hydrophiles. L'invention concerne en outre des compositions les renfermant, ainsi que la synthèse en phase solide de peptoïdes de structure variée utilisant des fragments de ligation chimiosélectifs.
Borden Ladner Gervais Llp
Chiron Corporation
Horn Thomas
LandOfFree
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