Peptides recognized by melanoma-specific cytotoxic...

Details Peptides recognized by melanoma-specific cytotoxic... Peptides recognized by melanoma-specific cytotoxic...

C - Chemistry, Metallurgy

07

K

C07K 14/74 (2006.01) A61K 38/08 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2182889

Melanoma-specific CTL epitopes have been identified through improvements in the art of identification of epitope-reconstituting peptides dissociated from MHC Class I molecules on the surface of the tumor cells. Peptides homologous with a segment of the melanoma/melanocyte antigen pMel-17 have proven to be highly potent stimulators of HLA-A2+CTL in several CTL cell lines. These and kindred peptides may be used to stimulate CTLs for use in adoptive immunotherapy, or incorporated into immunogenic conjugates for use as vaccines.

L'invention concerne les épitopes des lymphocytes T cytotoxiques, identifiés grâce aux progrès réalisés dans l'art et la technique de l'identification des épitopes. Ceux-ci permettent de reconstituter les peptides dissociés de molécules de la classe I du CMH, en surface des cellules tumorales. Des homologues de peptides avec une séquence de l'antigène pMel-17 du mélanome/mélanocyte se sont révélés de très puissants stimulants des lymphocytes T cytotoxiques du système HLA-A2?+¿dans plusieurs lignées cellulaires de ces lymphocytes. Ces homologues et des peptides apparentés peuvent être utilisés pour stimuler les lymphocytes T cytotoxiques dans une immunothérapie adoptive ou être incorporés dans des conjugués immunogéniques pour servir de vaccins.

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