Peptides related to somatostatin

C - Chemistry – Metallurgy – 07 – K

Patent

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530/7.26

C07K 14/655 (2006.01)

Patent

CA 1129846

X-4758 -1- Abstract of the Disclosure The tetradecapeptides of the formula Image (III) wherein X is H-Ala-D-Ala, H-D-Ala-Gly, or H-D-Val-Gly; and X1 is Ala-Leu, Ala-Phe, Ala-D-Phe, D-Ala-Phe, or D-Ala-Cha; or the non-toxic, pharmaceutically acceptable acid addition salts thereof; inhibit secretion of growth hormone, while not materially inhibiting the secretion of insulin or glucagon. Intermediates used in the synthesis of the tetradecapeptides are also described.

336401

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