C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2077651
An epitope in the human immunodeficiency virus-1 (HIV-1) reverse transcriptase that is conserved among HIV strains and that is recognized by both murine and human cytotoxic T cells has been identified. Peptides that are derived from this epitope and that are capable of eliciting cytotoxic T cells that kill cells that express reverse transcriptase are provided. Test kits and meth- ods for identifying HIV-infected individuals using the peptides are also provided. The optimal antigenic side of the HIV-1 reverse transcriptase, which was identified using a murine antigen-specific CD8 + Class I MHC-molecule-restricted cytotoxic T-cell line, includes residues 203-219. This peptide was recognized by cytotoxic lymphocytes from HIV seropositive individuals, but not by cytotoxic lymphocytes from seronegative individuals, and, thus provide a means for diagnosing HIV infection. Test kits and methods for identifying HIV-infected individuals using the peptides are provided. Peptides that include this antigenic site provide a means for producing an immunologic response against a broad range of HIV, and, therefore may be useful for inclusion in an AIDS vaccine. Compositions that contain these peptides and that are formulated for parenteral administration are provided.
Berzofsky Jay A.
Clerici Mario
Germain Ronald N.
Hosmalin Anne
Moss Bernard
Borden Ladner Gervais Llp
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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