Peptides targeting specifically tumor-derived endothelial cells

Details Peptides targeting specifically tumor-derived endothelial cells Peptides targeting specifically tumor-derived endothelial cells

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/04 (2006.01) A61K 47/48 (2006.01) A61K 49/14 (2006.01) A61K 51/08 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2402327

Peptide motifs which define specificity of tumor-derived endothelial cells. These peptides possess a charge motif of positive-positive-hydrophobic which is important in determining the specificity of binding to tumor-derived endothelium. The specific molecular peptide motifs will facilitate diverse therapeutic and diagnostic applications including: anti-angiogenic therapies to be used in alone or in conjunction with standard therapies; imaging tools for both detection of very small metastasis that are undetectable by current techniques; for monitoring tumor response; for targeting and directing chemotherapy drugs to the tumor; for treatment of chronic inflammatory diseases such as rheumatoid arthritis and psoriasis, for treating some forms of blindness; as well as other diagnostic and therapeutic applications.

L'invention concerne des motifs peptidiques définissant la spécificité de cellules endothéliales dérivées de tumeurs. Ces peptides possèdent un motif de charge positif-positif-neutre hydrophobe qui est important pour déterminer la spécificité de liaison à un endothélium tumoral. Les motifs peptidiques moléculaires spécifiques facilitent diverses applications thérapeutiques et de diagnostics comprenant: des thérapies anti-angiogéniques à réaliser seules ou en combinaison avec des thérapies standards, des outils d'imagerie destinés à la fois à la détection de très petites métastases non détectables par des techniques courantes et au suivi de réponse tumorale, le ciblage et l'orientation de médicaments de chimiothérapie vers la tumeur, le traitement de maladies inflammatoires chroniques telles que l'arthrite rhumatoïde et le psoriasis, le traitement de certaines formes cécité, et d'autres applications thérapeutiques et de diagnostics.

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