Peptides that bind to the erythropoietin receptor

Details Peptides that bind to the erythropoietin receptor Peptides that bind to the erythropoietin receptor

C - Chemistry, Metallurgy

07

K

C07K 14/505 (2006.01) A61K 38/18 (2006.01) A61P 7/06 (2006.01)

Patent

CA 2525497

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. The peptides can be in monomeric or dimeric forms and are eventually conjugated to PEG. The peptides have from 1 to 40 residues and comprise the sequence: LYACHX0GPITX1VCQPLR, wherein X0 is H or homoserine methylether; X1 is W or 1-nal or 2-nal.

L'invention porte sur des composés de peptides agonistes du récepteur de l'érythropoïétine (EPO-R), sur des méthodes thérapeutiques utilisant lesdits composés pour traiter les troubles associés à une production insuffisante ou défectueuse de globules rouges, et sur des préparations pharmaceutiques comprenant lesdits composés.

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