Peptides that block the binding of igg to fcrn

Details Peptides that block the binding of igg to fcrn Peptides that block the binding of igg to fcrn

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2638867

The invention relates to peptides which bind to human FcRn and inhibit binding of the Fc portion of an IgG to an FcRn, thereby modulating serum IgG levels. The disclosed compositions and methods may be used for example, in treating autoimmune diseases and inflammatory disorders. The invention also relates to methods of using and methods of making the peptides of the invention.

L'invention concerne des peptides qui se lient au FcRn humain et inhibent la liaison du fragment Fc d'une IgG à un FcRn afin de moduler ainsi les taux d'IgG sériques. Les compositions et les procédés de l'invention peuvent être utilisés par exemple dans le traitement de maladies auto-immunes et de troubles inflammatoires. L'invention concerne également des procédés d'utilisation et des procédés de préparation des peptides de l'invention.

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