Peptides that induce antibodies which neutralize genetically...

Details Peptides that induce antibodies which neutralize genetically... Peptides that induce antibodies which neutralize genetically...

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 39/145 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) C07K 14/02 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) C12N 9/24 (2006.01) C12N 15/62 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2096159

This invention refers to peptides that induce antibodies which neutralize genetically divergent HIV-1 isolates. These peptides are applied with an adjuvant, as recombinant fusion proteins, chemically coupled to carrier molecules, as recombinant chimeric viruses or as recombinant antibodies. In addition, the stage of infection can be determined and the progression of the infection can be predicted with these peptides. Peptides binding to antibodies that show neutralizing activity against different strains and clinical isolates of HIV-1 and that inhibit the fusion of cells caused by HIV-1, characterized in that said peptides are composed according to one of the SEQ ID NO: 1 through SEQ ID NO: 25.

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