Peptides that inhibit complement activation

Details Peptides that inhibit complement activation Peptides that inhibit complement activation

A - Human Necessities

61

K

A61K 38/02 (2006.01) A61K 38/03 (2006.01) A61K 38/55 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2579635

The present invention relates to compositions, including pharmaceutical compositions that inhibit complement activation, and contain amino acid sequences X1 - X2 - X3 -W - E - X4 - X5 - X6 and/or Z1 - C1 - Z2 - P - Z3 - Z4- C2 - Z5 as described. The invention further relates to methods of inhibiting complement activation in vivo or ex vivo by administering a pharmaceutical composition as described herein.

L'invention concerne des compositions, notamment des compositions pharmaceutiques, permettant d'inhiber l'activation du complément, et contenant les séquences d'acide aminé X¿1? - X¿2? - X¿3? -W - E - X¿4? - X¿5? - X¿6? et/ou Z¿1? - C¿1? - Z¿2? - P - Z¿3? - Z¿4 ?- C¿2? - Z¿5?. L'invention concerne également des méthodes permettant d'inhiber l'activation du complément in vivo ou ex vivo par administration de la composition pharmaceutique précitée.

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