C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) A61K 39/42 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2140151
The invention provides a molecule comprising a peptide having the amino acid sequence lysine-proline- cysteine-valine-lysine-leucine-threonine-proline-leucine- cysteine-valine (Seq.Id.No.1), wherein each cysteine resi- due is disulphide bridged to a further cysteine residue or is derivatised to simulate part of a disulphide bond, or functionally equivalent variants of such a peptide which mimic the immunogenic behaviour of an epitope of gp120 of HIV env. The sequence is highly conserved, being total- ly conserved in all listed isolates of HIV-1 and HIV-2, and undergoes only minor changes in isolates of SIV. With each cysteine residue contributing to a respective disulphide bridge (actual or simulated by suitable deriva- tisation), the molecule accurately mimics behaviour of the corresponding sequence of gp120 and elicits an immune response. The molecule can thus be used as the basis of a potential vaccine against AIDS and AIDS related condi- tions, and may find use in the treatment of AIDS and re- lated conditions.
Butler Peter J. G.
Hacking Graeme N. V.
Kirby Eades Gale Baker
Medical Research Council
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