Peptides that mimic non-human cross-reactive protective...

Details Peptides that mimic non-human cross-reactive protective... Peptides that mimic non-human cross-reactive protective...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 39/095 (2006.01)

Patent

CA 2654289

Peptides that mimic the antigenic features of non human-cross-reactive protective epitopes of the MenB CP and nucleic acids encoding the peptide mimetics are disclosed. Antibodies elicited by these peptides do not bind to polysialic acid in host tissue and thus provide a safe and efficacious method for the treatment and/or prevention of Meningitis B.

La présente invention concerne des peptides qui reproduisent les caractéristiques antigéniques des épitopes protecteurs à réactivité croisée non humains du PC MenB, ainsi que des acides nucléiques codant pour les peptides mimétiques. Les anticorps obtenus grâce à ces peptides ne se lient pas à l'acide polysialique présent dans les tissus de l'hôte et ils conduisent par conséquent à un procédé efficace et sans danger permettant de traiter et/ou de prévenir la méningite B. figure 1, ne rien traduire sauf seam = joint

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