C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C12N 15/09 (2006.01) G01N 33/53 (2006.01) A61K 31/475 (2006.01) A61K 31/704 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2678051
The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCED mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCED mice.
L'invention concerne des acides nucléiques, des peptides et des anticorps pour une utilisation dans des applications comprenant un diagnostic et un traitement. Les peptides ciblent le système néovasculaire et sont identifiés par un affichage de bactériophage in vivo. Un de ces peptides, SP5-52, a reconnu le système néovasculaire de multiples tumeurs chez des souris SCED, mais n'a pas ciblé les vaisseaux sanguins normaux. Ce peptide se lie également aux vaisseaux sanguins des échantillons de biopsie du cancer du poumon humain. Les liposomes comprenant SP5-52 et la doxorubicine ont renforcé l'efficacité du médicament vis-à-vis des xénogreffes de cancer humain multiples chez des souris SCED. =
Kuo Szu-Yao
Lee Tong-Young
Lin Chin-Tarng
Wu Han-Chung
Academia Sinica
Gowling Lafleur Henderson Llp
National Taiwan University
LandOfFree
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