Peptides tolerizing t-cells and compositions thereof

Details Peptides tolerizing t-cells and compositions thereof Peptides tolerizing t-cells and compositions thereof

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 14/805 (2006.01)

Patent

CA 2144409

The present invention provides a tolerizing peptide and a therapeutic composition containing at least one such tolerizing peptide which when administered to an individual in a therapeutically effective amount is capable of tolerizing at least a portion and preferably all of the T cells of said individual which are specific for an antigen (e.g. an allergen, an autoantigen or a trans- plantation antigen), said tolerizing peptide having the ability to combine with MHC proteins on antigen presenting cells (APC) and cause binding of T cell receptors on at least a portion of the T cells of an individual to said peptide-MHC complex. Said tol- erizing peptide preferably has the ability to cause no detectable or minimal proliferation of at least a portion of the T cells of an individual which are specific for said antigen when said peptide is administered in vivo in immunogenic form. The invention also provides a method for treating sensitivity to a particular antigen in an individual and a method for tolerizing at least a portion of a population of T cells in an individual which are specific for an antigen.

Affiliated with

Also associated with

Rating

Peptides tolerizing t-cells and compositions thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides tolerizing t-cells and compositions thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides tolerizing t-cells and compositions thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1524044