C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 39/02 (2006.01) A61K 39/385 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/245 (2006.01)
Patent
CA 2191202
The invention relates to conjugates of poorly immunogenic antigens, e.g., peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the sequence of E. coli hsp65 (GroEL), or an analog thereof, said peptide or analog being capable of increasing substantially the immunogenicity of the poorly immunogenic antigen. A suitable peptide according to the invention is Pep287e, which corresponds to positions 437-453 of the E. coli hsp65 molecule.
L'invention concerne des conjugués d'antigènes faiblement immunogènes, par exemple des peptides, protéines et polysaccharides, comprenant un porteur de peptide de synthèse constituant un épitope de lymphocyte T dérivé de la séquence d'E. coli hsp65 (GroEL), ou analogue, ledit peptide ou analogue pouvant accroître considérablement l'immunogénicité de l'antigène faiblement immunogène. Pep278e, correspondant aux positions 437-453 de la molécule d'E. coli hsp65 constitue un peptide approprié selon l'invention.
Cohen Irun R.
Fridkin Matityahu
Konen-Waisman Stephanie
Ltd. Yeda Research And Development Co.
Osler Hoskin & Harcourt Llp
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