Peptides useful for inducing tolerance

Details Peptides useful for inducing tolerance Peptides useful for inducing tolerance

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 39/00 (2006.01) A61K 39/35 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2132873

2132873 9319178 PCTABS00025 The present invention is based on the discovery that subcutaneous administration of a peptide comprising at least one T cell epitope of a protein allergen or other protein antigen results in T cell tolerance upon subsequent exposure to the allergen or other antigen. Peptides useful for inducing tolerance in a mammal, such as a human by subcutaneous administration or other routes of administration are within the scope of this invention. Such peptides include peptide X (SEQ ID NO: 7), peptide Y (SEQ ID NO: 8), peptide Z (SEQ ID NO: 9), peptide A (SEQ ID NO: 10), peptide B (SEQ ID NO: 11), peptide C (SEQ ID NO: 12), peptide D (SEQ ID NO: 13), and peptide E (SEQ ID NO: 14), each as shown in the figure. It is preferred that such peptides be administered in soluble form.

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