Peptides useful for reducing symptoms of toxic shock...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/085 (2006.01) A61K 39/09 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2345023

This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof. The invention also relates to serum antibodies induced by the peptides and carrier-conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins. The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates isolated and purified to nucleic acids encoding the peptides of the invention and transformed host cells containing those nucleic acids.

Cette invention concerne des compositions et des méthodes qui protègent contre le choc toxique staphylococcique ou contre le choc septique, ou qui en atténuent la gravité. Elle concerne plus particulièrement des peptides tirés de séquences homologues de la famille des toxines d'origine staphylococcique et streptococcique, qui peuvent être des polymères et des conjugués de ces peptides. Cette invention concerne également des anticorps sériques induits par les peptides et les conjugués porteurs et leur action préventive, thérapeutique et protectrice à l'égard de la plupart, si ce n'est la totalité, des toxines d'origine staphylococcique et streptococcique. L'invention concerne également des essais et des kits de diagnostic permettant de détecter la présence de toxines d'origine staphylococcique et streptococcique, ou d'anticorps de ces toxines. De plus, elle concerne également des acides nucléiques isolés et purifiés codant pour les peptides selon l'invention et des cellules hôtes transformées codant pour ces acides nucléiques.

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