Peptides useful for reducing symptoms of toxic shock syndrome

Details Peptides useful for reducing symptoms of toxic shock syndrome Peptides useful for reducing symptoms of toxic shock syndrome

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/085 (2006.01) A61K 39/09 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2286346

This invention relates to compositions and methods for eliciting an immunogenic response in mammals, including responses which provide protection against, or reduce the severity, of toxic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphylococcal and streptococcal toxins, which may be polymeric, and carrier-conjugates thereof, and their use to induce serum antibodies. The invention also relates to serum antibodies induced by the peptides and carrier- conjugates and their use to prevent, treat, or protect against the toxic effects of most, if not all, of the staphylococcal and streptococcal toxins. The invention also relates to diagnostic assays and kits to detect the presence of staphylococcal and streptococcal toxins, or antibodies thereto. The invention also relates to isolated and purified nucleic acids encoding the peptides of the invention and transformed host cells containing those nucleic acids.

Cette invention concerne des compositions et des méthodes servant à déclencher une réponse immunogène chez des mammifères, y compris une réponse pouvant fournir une protection contre un choc toxique dû à des infections bactériennes, ou en réduire la gravité. Plus particulièrement, l'invention concerne des peptides, éventuellement polymériques, issus de séquences homologues de la famille des toxines staphylococciques ou streptococciques, et des conjugués-porteurs desdits peptides, ainsi que leur utilisation pour activer des anticorps sériques. L'invention concerne également des anticorps sériques activés par lesdits peptides et conjugués-porteurs, et leur utilisation pour prévenir, traiter, ou protéger des effets toxiques de la plupart (sinon de la totalité) des toxines staphylococciques ou streptococciques. L'invention concerne en outre des doses diagnostiques et des trousses permettant de détecter la présence de toxines staphylococciques ou streptococciques ou leurs anticorps. L'invention concerne enfin des acides nucléiques isolés et purifiés codant lesdits peptides, ainsi que des cellules hôtes contenant ces acides nucléiques.

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