Peptides useful in treating multiple sclerosis and a...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

IPC codes

C07K 14/47 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61P 25/28 (2006.01) C07K 7/08 (2006.01)

Type

Patent

Patent number

CA 2367003

Description

A peptide compound useful in treating the Multiple Sclerosis selected from the group comprising: R-Asn-Gly-Val-Gly-His-Gly-Phe-Gly-Asn-Gly-Val-Gly-Pro-Gly-Thr-Gly-Pro-Gly-Ser- Gly-R' (I) (SEQ ID NO: 1); R-Gly-Pro-Gly-Val-Gly-Phe-Gly-Lys-Gly-Ile-Gly-Thr-Gly-Arg-Gly-Pro-Gly-Pro-Gly- Gln-R' (II) (SEQ ID NO: 2); R-Gln-Gly-Pro-Gly-Pro-Gly-Arg-Gly-Thr-Gly-Ile-Gly-Lys-Gly-Phe-Gly-Val-Gly-Pro- Gly-R' (III) (SEQ ID NO:3); and R-Gly-Ser-Gly-Pro-Gly-Thr-Gly-Pro-Gly-Val-Gly-Asn-Gly-Gly-Phe-Gly-His-Gly-Val- Gly-Asn-R' (IV) (SEQ ID NO:4) where R is H- or COCH3, R' is COOH or CONH2 and each amino acid has L or D configuration. A pharmaceutical composition comprising the same.

L'invention concerne un composé de peptide utile au traitement de la sclérose en plaque sélectionné dans le groupe contenant: R-Asn-Gly-Val-Gly-His-Gly-Phe-Gly-Asn-Gly-Val-Gly-Pro-Gly-Thr-Gly-Pro-Gly-Ser-Gly-R' (I) (SEQ ID NO: 1) R-Gly-Pro-Gly-Val-Gly-Phe-Gly-Lys-Gly-Ile-Gly-Thr-Gly-Arg-Gly-Pro-Gly-Pro-Gly-Gln-R' (II) (SEQ ID NO: 2) R-Gln-Gly-Pro-Gly-Pro-Gly-Arg-Gly-Thr-Gly-Ile-Gly-Lys-Gly-Phe-Gly-Val-Gly-Pro-Gly-R', et (III) (SEQ ID NO:3) R-Gly-Ser-Gly-Pro-Gly-Thr-Gly-Thr-Gly-Pro-Gly-Val-Gly-Asn-Gly-Gly-Phe-Gly-His-Gly-Val-Gly-Asn-R' (IV) (SEQ ID NO:4) où R représente H- ou COCH3, R' représente COOH ou CONH2 et chaque acide aminé possède une configuration en L ou D. Cette invention concerne également une composition pharmaceutique correspondante.

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