Peptides which bind to prothrombin and thrombin

Details Peptides which bind to prothrombin and thrombin Peptides which bind to prothrombin and thrombin

C - Chemistry, Metallurgy

12

N

C12N 9/74 (2006.01) C07K 7/06 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2206663

Peptide ligands which bind to thrombin and prothrombin are disclosed. The sequences of these peptides are Gln-Leu-Trp-Gly-Ser-His, Arg-Gln-Leu-Trp-Gly-Ser-His, His-Gln-Leu-Trp-Gly-Ser-His, and Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. The preferred peptides have the sequence Gln-Leu-Trp-Gly-Ser-His or Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. A method of using these peptides in an affinity chromatography process to purify thrombin is described.

L'invention divulgue des ligands peptidiques qui se fixent à la thrombine et à la prothrombine. Les séquences de ces peptides sont Gln-Leu-Trp-Gly-Ser-His, Arg-Gln-Leu-Trp-Gly-Ser-His, His-Gln-Leu-Trp-Gly-Ser-His, et Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. Les peptides préférés renferment la séquence Gln-Leu-Trp-Gly-Ser-His ou Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. Une méthode d'utilisation de ces peptides dans un procédé de chromatographie d'affinité pour purifier la thrombine est décrite.

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