Peptides with a bradykinin-antagonistic action

Details Peptides with a bradykinin-antagonistic action Peptides with a bradykinin-antagonistic action

C - Chemistry, Metallurgy

07

K

C07K 7/18 (2006.01) A61K 38/08 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2041268

Peptides with a bradykinin-antagonistic action Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I ~~(I) in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulfonyl, cycloalkyl, aryl, arylsulfonyl, heteroaryl or an amino acid, each of which can optionally be substi- tuted, B is a basic amino acid, C is a di- or tripeptide E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or a direct bond, G is an amino acid, F' is as defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO- or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin or bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

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