Peptides with antiproliferative properties

Details Peptides with antiproliferative properties Peptides with antiproliferative properties

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2251691

The present invention relates to antiproliferative peptides which are derived from a tumour-suppressor protein and bond to growth factor or growth factor- receptor segments. The invention also relates to nucleic acids (DNAs/RNAs) which code for these peptides and structurally homologous peptide nucleic acids and pharmaceutical compositions containing such peptides. The invention can be used in biotechnology, molecular biology, bioinformatics and in diagnosis and therapy of hyperproliferative disorders, in particular cancer and atherosclerosis.

L'invention concerne des peptides antiprolifératifs, qui sont dérivés d'une protéine suppresseur de tumeur et qui se lient à des segments du facteur de croissance ou du récepteur du facteur de croissance. Elle concerne également des acides nucléiques (ADN/ARN) codant pour lesdits peptides, ainsi que des acides nucléiques peptidiques structuralement homologues desdits peptides et des compositions pharmaceutiques contenant lesdits peptides. Elle trouve des applications en biotechnologie, biologie moléculaire, bio-informatique, ainsi que pour le diagnostic et le traitement des maladies prolifératives, notamment le cancer et l'athérosclérose.

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