Peptides with .beta.1 integrin subunit dependent cell...

Details Peptides with .beta.1 integrin subunit dependent cell... Peptides with .beta.1 integrin subunit dependent cell...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 5/06 (2006.01) C07K 5/09 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2319207

Peptides capable of modulating .beta.1 integrin subunit dependent cell adhesion which includes a C-terminal aromatic amino acid residue and an amino acid residue having a lipophilic alkyl side chain as the penultimate C- terminal residue are provided. These "LipAr" C-terminated peptides are typically capable of modulating the .beta.1 integrin subunit dependent adhesion of cells, such as Ramos cells.

L'invention concerne des peptides capables de moduler l'adhérence des cellules dépendant de la sous-unité d'intégrine .beta. qui comprennent un résidu d'acides aminés aromatiques à terminal C et un résidu d'acides aminés possédant une chaîne latérale d'alkyle lipophile se présentant comme un dernier résidu du terminal C. Ces peptides "LipAr" à terminaison C sont, en règle générale, capables de moduler l'adhérence des cellules dépendant de la sous-unité d'intégrine .beta., par exemple des cellules de Ramos.

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