Peptides with disulfide bridges and method

Details Peptides with disulfide bridges and method Peptides with disulfide bridges and method

C - Chemistry, Metallurgy

07

K

530/7.04, 530/7.

C07K 7/04 (2006.01) C07K 1/02 (2006.01) C07K 1/06 (2006.01) C07K 14/585 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1255850

ABSTRACT OF THE DISCLOSURE Peptides, such as calcitonin, having two cysteine residues connected by a disulfide bond are prepared by a process which includes the step of cyclizing the cysteines at a pH of 8.5 to 9.0, and a concentration of 0.4 to 1.8 mg of peptide per ml of solution. These novel conditions produce rapid cyclization with an unforeseen improvement in yield.

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