C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61L 27/22 (2006.01) A61L 27/34 (2006.01) A61P 35/00 (2006.01) C07K 5/10 (2006.01) C07K 5/11 (2006.01) C07K 7/06 (2006.01) C07K 14/49 (2006.01) C07K 17/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2468187
Peptides and peptide compositions are identified which inhibit the growth of abnormal cells. In one embodiment, the peptides are useful for inhibiting the growth of cells dependent on autocrine activation of the PDGF receptor. Such peptides may be used in the treatment of cell proliferative disorders including cancer, fibrotic disorders, myeloproliferative diseases and blood vessel proliferative (angiogenic) disorders characterized by inappropriate PDGF receptor activity. A biomedical device is further disclosed which has associated with it a peptide or peptide composition according to the present invention.
L'invention concerne des peptides et des compositions peptidiques identifiés inhibant la croissance de cellules anormales. Dans un mode de réalisation, les peptides sont utiles pour inhiber la croissance de cellules en fonction de l'activation d'autocrine du récepteur PDGF. De tels peptides peuvent être utilisés pour traiter des troubles de la prolifération cellulaire, parmi lesquels, le cancer, les troubles fibreux, les syndromes myéloprolifératifs, et les troubles (angiogéniques) prolifératifs des vaisseaux sanguins, qui se caractérisent par une activité inadéquate du récepteur PDGF. La présente invention concerne également un dispositif biomédical auquel est associé un peptide ou une composition peptidique de l'invention.
Dean Cheryl
Haaland Perry D.
Heidaran Mohammad
Spargo Catherine A.
Becton Dickinson And Company
Gowling Lafleur Henderson Llp
Haaland Perry D.
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