Peptides with growth promotion properties

Details Peptides with growth promotion properties Peptides with growth promotion properties

C - Chemistry, Metallurgy

07

K

C07K 14/61 (2006.01) A61K 38/10 (2006.01) A61K 38/27 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2216755

Peptides are described which have well-defined secondary structure, preferably a helical conformation, which mimic the corresponding region of porcine somatotropin (pST) and which enhance the activity of pST and promote growth of warm-blooded animals. These peptides compete with pST for binding to the PS- 7.6 monoclonal antibody. These peptides contain therein the sequence of amino acids Xaa-Xaa-Leu-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Val-Xaa-Xaa (SEQ ID No. 1), wherein the sequence differs from the native sequence of pST, as well as sequences in which the location of essential amino acids is shifted by three amino acids, representing almost one turn along the helix, which contain therein the sequence of amino acids Xaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Ile- Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Val (SEQ ID No. 18) and wherein the sequence differs from the native sequence of pST.

L'invention concerne des peptides qui ont une structure secondaire bien définie (de préférence avec une conformation hélicoïdale) et similaire à celle de la région correspondante de la somatotropine porcine (pST) et qui favorisent l'activité de la pST et la croissance des animaux à sang chaud. Ces peptides entrent en compétition avec la pST pour la fixation à l'anticorps monoclonal PS-7,6. Ces peptides contiennent la séquence des acides aminés Xaa-Xaa-Leu-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Val-Xaa-Xaa (SEQ ID No. 1) qui diffère de la séquence de la pST native, ainsi que des séquences dans lesquelles l'emplacement d'acides aminés essentiels est déplacé de trois acides aminés (ce qui représente presqu'un tour sur l'hélice) et qui contiennent la séquence des acides aminés Xaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Ile-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Val (SEQ ID No. 18), qui diffère de la séquence de la pST native.

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