Peptides with the capacity to bind to transforming growth...

Details Peptides with the capacity to bind to transforming growth... Peptides with the capacity to bind to transforming growth...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 1/16 (2006.01) A61P 43/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2535807

The invention relates to peptides which can bind to transforming growth factor TGF-.beta.1 (TGF-.beta.1) and which are potential inhibitors of the biological activity of TGF-.beta.1 by means of direct binding to the aforementioned cytokine. The inventive peptides can be used in the treatment of pathological alterations or diseases based on a deregulated or excessive expression of TGF- .beta.1.

L'invention concerne des peptides qui sont capables de se fixer au facteur de croissance transformant TGF-.beta.1 (TGF-.beta.1) et qui sont des inhibiteurs potentiels de l'activité biologique du TGF-.beta.1 par fixation directe de ce dernier à ladite cytokine. Ces peptides peuvent être utilisés dans le traitement de maladies ou d'altérations pathologiques basées sur une expression excessive ou dérégulée du TGF-.beta.1.

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