C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2459230
The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XAxA3A1A2A1Y, or a functional equivalent of said peptide. In addition, the invention relates to methods for preparing such compounds, to the use of such compounds in therapeutic or diagnostic methods and in pharmaceutical compositions, to nucleic acids encoding for proteinaceous materials comprising the amino acid sequences of said compounds, to gene delivery vehicles comprising such nucleic acids, to binding molecules binding to said compounds, and to a method for determining whether a compound is capable of binding to P-selectin.
La présente invention concerne des composés qui se fixent de manière sélective à la molécule d'adhésion de la P-sélectine humaine, et notamment de tels composés comprenant un peptide présentant une séquence d'acides aminés XA¿x?A¿3?A¿1?A¿2?A¿1?Y, ou un équivalent fonctionnel dudit peptide. De plus, l'invention concerne des méthodes de préparation desdits composés, l'utilisation desdits composés dans des méthodes thérapeutiques ou diagnostiques et dans des compositions pharmaceutiques, des acides nucléiques codant des matières protéiniques comprenant les séquences d'acides aminés desdits composés, des vecteurs de gènes comprenant lesdits acides nucléiques, des molécules de fixation se fixant auxdits composés et une méthode permettant de déterminer si un composé peut se fixer à la P-sélectine.
Biessen Erik Anna
Kuiper Johan
Molenaar Thomas Jacobus Maria
Van Berkel Theodorus Josephus Cornelis
Astellas Pharma Europe B.v.
Osler Hoskin & Harcourt Llp
Yamanouchi Europe B.v.
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