Peptidoglycan recognition proteins

Details Peptidoglycan recognition proteins Peptidoglycan recognition proteins

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 39/00 (2006.01) C07H 21/02 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/12 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01) C12P 21/06 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2356542

The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of Figures 1A-B, Figures 2A-C, and Figure 3, respectively, each having homology to both human <u>p</u>eptido<u>g</u>lycan <u>r</u>ecognition <u>p</u>rotein (PGRP) as well as murine Tag-7. PGRP-K, PGRP- W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP- W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP- W, and PGRP-C gene expression.

L'invention concerne trois nouvelles protéines de liaison de liaison de peptidoglycane, exprimées par les kératinocytes, les tissus en cours de cicatrisation et le tissu de chondrosarcome. L'invention porte, plus spécifiquement sur des molécules d'acide nucléique isolées, codant pour les protéines apparentées à la protéine de reconnaissance du peptidoglycane, appelées ici respectivement PGRP-K (kératinocytes), PGRP-W (cicatrisation) et PGRP-C (chondrosarcome), des figures 1A-B, des figures 2A-C, et de la figure 3, chacune ayant une homologie avec la protéine de reconnaissance du peptidoglycane humain (PGRP) et avec l'étiquette 7 de la souris. Des polypeptides de PGRP-K, PGRP-W et PGRP-C sont également décrits ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison pour la production de ceux-ci. L'invention se rapporte aussi à l'inhibition et à l'augmentation des activités des polypeptides de PGRP-K, PGRP-W et PGRP-C ainsi qu'à des méthodes diagnostiques pour la détection de l'expression génique de PGRP-K, PGRP-W et PGRP-C.

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